Ajla Aksamija presented a keynote address at the Mass Timber Enclosure Symposium, organized by the RDH Science on November 16, 2021. Her presentation “Wood Enclosure Systems: Design and Research Considerations” discussed the applications of wood in building enclosures, as well as design and building science considerations in relation to high-performance facades. It is necessary to start differentiating operational energy use of buildings vs. embodied energy as we strive to decarbonize the built environment. Wood, as a natural and renewable material, can be used effectively to decrease embodied energy of building skins and improve their overall environmental impact. Advances in wood and wood-based composite materials, fabrication techniques, and construction methods are offering new solutions for integrating wood into building skins, including cladding and framing components. This keynote presentation illustrated design methods with case studies and provided insights from recent research and future directions.